Eureka: Undergraduates can publish too!

It's never too late to publish an abandoned trial

It is estimated that half of all trials have never been published which can lead to patients being denied the most effective treatment and being exposed to unnecessary side effects.  Furthermore the trial participants have been misinformed since the trial results have not contributed to the care of future patients. However the non-publication of trials is often not due to a deliberate decision ...

C2 Can Do It, Too

In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains ...

Testing Can Be Formal, Too

The paper presents a theory of program testing based on formal specifications. The formal semantics of the specifications is the basis for a notion of an exhaustive test set. Under some minimal hypotheses on the program under test, the success of this test set is equivalent to the satisfaction of the specification. The selection of a finite subset of the exhaustive test set can be seen as the i...

Can We Be Too Careful?

Too Much Information Can Be Too Much for Learning Eciently

In designing learning algorithms it seems quite reasonable to construct them in a way such that all data the algorithm already has obtained are correctly and completely re ected in the description the algorithm outputs on these data. However, this approach may totally fail, i.e., it may lead to the unsolvability of the learning problem, or it may exclude any e cient solution of it. In particula...